journal articles
CONTINUOUS ASSOCIATIONS BETWEEN REMOTE SELFADMINISTERED COGNITIVE MEASURES AND IMAGING BIOMARKERS OF ALZHEIMER’S DISEASE
E.A. Boots, R.D. Frank, W.Z. Fan, T.J. Christianson, W.K. Kremers, J.L. Stricker, M.M. Machulda, J.A. Fields, J. Hassenstab, J. Graff-Radford, P. Vemuri, C.R. Jack, D.S. Knopman, R.C. Petersen, N.H. Stricker
J Prev Alz Dis 2024;5(11):1467-1479
BACKGROUND: Easily accessible and self-administered cognitive assessments that can aid early detection for Alzheimer’s disease (AD) dementia risk are critical for timely intervention.
OBJECTIVES/DESIGN: This cross-sectional study investigated continuous associations between Mayo Test Drive (MTD) – a remote, self-administered, multi-device compatible, web-based cognitive assessment – and AD-related imaging biomarkers.
PARTICIPANTS/SETTING: 684 adults from the Mayo Clinic Study of Aging and Mayo Clinic Alzheimer’s Disease Research Center participated (age=70.4±11.2, 49.7% female). Participants were predominantly cognitively unimpaired (CU; 94.0%).
MEASUREMENTS: Participants completed (1) brain amyloid and tau PET scans and MRI scans for hippocampal volume (HV) and white matter hyperintensities (WMH); (2) MTD remotely, consisting of the Stricker Learning Span and Symbols Test which combine into an MTD composite; and (3) in-person neuropsychological assessment including measures to obtain Mayo Preclinical Alzheimer’s disease Cognitive Composite (Mayo-PACC) and Global-z. Multiple regressions adjusted for age, sex, and education queried associations between imaging biomarkers and scores from remote and in-person cognitive measures.
RESULTS: Lower performances on MTD were associated with greater amyloid, entorhinal tau, and global tau PET burden, lower HV, and higher WMH. Mayo-PACC and Global-z were associated with all imaging biomarkers except global tau PET burden. MCI/Dementia participants showed lower performance on all MTD measures compared to CU with large effect sizes (Hedge’s g’s=1.65-2.02), with similar findings for CU versus MCI only (Hedge’s g’s=1.46-1.83).
CONCLUSION: MTD is associated with continuous measures of AD-related imaging biomarkers, demonstrating ability to detect subtle cognitive change using a brief, remote assessment in predominantly CU individuals and criterion validity for MTD.
CITATION:
E.A. Boots ; R.D. Frank ; W.Z. Fan ; T.J. Christianson ; W.K. Kremers ; J.L. Stricker ; M.M. Machulda ; J.A. Fields ; J. Hassenstab ; J. Graff-Radford ; P. Vemuri ; C.R. Jack ; D.S. Knopman ; R.C. Petersen ; N.H. Stricker (2024): Continuous Associations between Remote Self-Administered Cognitive Measures and Imaging Biomarkers of Alzheimer’s Disease. The Journal of Prevention of Alzheimer’s Disease (JPAD). http://dx.doi.org/10.14283/jpad.2024.99