journal articles
PLASMA AMYLOID-Β PRECURSOR PROTEIN 669–711/AMYLOID-Β1–42 RATIO IS ASSOCIATED WITH COGNITION IN ALZHEIMER\'S DISEASE
Moeko Noguchi-Shinohara, Yasuhiro Sakashita, Hiroto Nakano, Daiki Muramatsu, Sadao Hikishima, Junji Komatsu, Hidetomo Murakami, Yukiko Mori, Kenjiro Ono
J Prev Alz Dis 2025;1(12)
Plasma amyloid-β (Aβ) markers are significant predictors of Aβ pathology. However, their prognostic value for cognition in patients with Alzheimer's disease (AD) is unknown. We compared plasma amyloid-β precursor protein (APP)669–711 and Aβ1–42 levels between cognitively unimpaired participants (CU) and those with MCI due to AD and AD dementia. The CU group was divided into CU+ or CU- groups according to presence of Aβ pathology. All patients with AD exhibited Aβ pathology. The plasma APP669–711/Aβ1–42 ratio was significantly elevated in patients with CU+, MCI+, and AD+ compared with those with CU-. Furthermore, the plasma APP669–711/Aβ1–42 ratio was significantly correlated with the MMSE score (rs = −0.544, p < 0.001). Analysis of the Aβ+ group revealed that the significant relationship between MMSE score and plasma APP669–711/Aβ1–42 ratio remained unchanged (rs = −0.244, p = 0.027). Therefore, we conclude that the plasma APP669–711/Aβ1–42 ratio is associated with cognition in patients with AD.
CITATION:
Moeko Noguchi-Shinohara ; Yasuhiro Sakashita ; Hiroto Nakano ; Daiki Muramatsu ; Sadao Hikishima ; Junji Komatsu ; Hidetomo Murakami ; Yukiko Mori ; Kenjiro Ono (2025): Plasma amyloid-β precursor protein 669–711/amyloid-β1–42 ratio is associated with cognition in Alzheimer's disease. The Journal of Prevention of Alzheimer’s Disease (JPAD). https://doi.org/10.1016/j.tjpad.2024.100003