journal articles
DIETARY SUPPLEMENTATION AND THE ROLE OF PHYTOCHEMICALS AGAINST THE ALZHEIMER\'S DISEASE: FOCUS ON POLYPHENOLIC COMPOUNDS
Rayees Ahmad Naik, Roshni Rajpoot, Raj Kumar Koiri, Rima Bhardwaj, Abdullah F. Aldairi, Ayman K. Johargy, Hani Faidah, Ahmad O. Babalghith, Ahmed Hjazi, Walaa F. Alsanie, Abdulhakeem S. Alamri, Majid Alhomrani, Abdulaziz Alsharif, Anastasiia Shkodina, Sandeep Kumar Singh
J Prev Alz Dis 2025;1(12)
Alzheimer's disease is a complicated, multifaceted, neurodegenerative illness that places an increasing strain on healthcare systems. Due to increasing malfunction and death of nerve cells, the person suffering from Alzheimer's disease (AD) slowly and steadily loses their memories, cognitive functions and even their personality. Although medications may temporarily enhance memory, there are currently no permanent therapies that can halt or cure this irreversible neurodegenerative process. Nonetheless, fast progress in comprehending the cellular and molecular abnormalities responsible for neuronal degeneration has increased confidence in the development of viable prevention and treatments. All FDA-approved anti-AD medications have merely symptomatic effects and cannot cure the illness. This necessitates the pursuit of alternate treatments. Accumulating data shows that systemic neuroinflammation, oxidative stress and associated mitochondrial dysfunction play crucial roles in the etiology of AD and precede its clinical presentation. Therefore, innovative therapeutic approaches targeting these pathophysiological components of Alzheimer's disease are being explored aggressively in the present scenario. Phytochemicals such as resveratrol, curcumin, quercetin, genistein and catechins are prospective therapies owing to their capacity to alter key AD pathogenetic pathways, such as oxidative stress, neuroinflammation, and mitochondrial dysfunction. The use of new phytochemical delivery strategies would certainly provide the possibility to solve several issues with standard anti-AD medicines. In this review, the roles of phytophenolic compound-based treatment strategies for AD are discussed.
CITATION:
Rayees Ahmad Naik ; Roshni Rajpoot ; Raj Kumar Koiri ; Rima Bhardwaj ; Abdullah F. Aldairi ; Ayman K. Johargy ; Hani Faidah ; Ahmad O. Babalghith ; Ahmed Hjazi ; Walaa F. Alsanie ; Abdulhakeem S. Alamri ; Majid Alhomrani ; Abdulaziz Alsharif ; Anastasiia Shkodina ; Sandeep Kumar Singh (2025): Dietary supplementation and the role of phytochemicals against the Alzheimer's disease: Focus on polyphenolic compounds. The Journal of Prevention of Alzheimer’s Disease (JPAD). https://doi.org/10.1016/j.tjpad.2024.100004